Hi Amy,<br> <br> Three weeks would be about the earliest he would see changes. He should give it the full three months before deciding that the treatment isn't working. In the meantime, the two of you should check out our "symptom tracker" -- by filling out this questionnaire and saving the results each month, you both can see if there are real changes going on. Here's the URL: <a href="http://www.seekwellness.com/andropause/ams_quiz.htm" target="_blank">http://www.seekwellness.com/andropause/ams_quiz.htm</a><br> Good luck and I'd love it if you kept us posted on his progress.