I found several studies in the National Library of Medicine that indicate that statin therapy to lower cholesterol has no effect on testosterone production. Here's an example:<br> <br> Does statin therapy influence steroid hormone synthesis?<br> <br> Bohm M, Herrmann W, Wassmann S, Laufs U, Nickenig G.<br> <br> Klinik fur Innere Medizin III, Universitatskliniken des Saarlandes, Kirrberger Strasse, 66421 Homburg, Germany. boehm@med-in.uni-saarland.de<br> <br> Statins reduce cholesterol and isoprenoid de novo biosynthesis as well as receptor mediated uptake of cholesterol for steroidogenesis. The present randomized placebo-controlled trial investigated whether pravastatin (40 mg/day) reduces the plasma concentrations of steroid hormones as well as of gonadotropins. Patients (n = 22; 15 males, 7 females) were treated with pravastatin (40 mg/day) or placebo. Levels of total and LDL cholesterol, the steroid hormones estradiol, testosterone, cortisol and dehydroepiandrosterone sulphate (DHEAS) as well as FSH and LH were studied. Pravastatin led to a significant reduction of total cholesterol and LDL cholesterol. There was no significant change in estradiol, testosterone, cortisol or DHEAS plasma concentrations. There was no compensatory change in FSH or LH. It is concluded that pravastatin does not alter steroid hormones or gonadotropins in a clinically applicable dose, which significantly reduces total and LDL cholesterol.